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IPFS News Link • Drugs and Medications

Over-the-counter antihistamine repairs nerve damage caused by MS

•, By Paul McClure

The researchers also identified a biomarker that can be used to measure the drug's effectiveness, opening the door to a potential new treatment for the debilitating disease.

In the autoimmune disease multiple sclerosis (MS), the body's immune system attacks the protective myelin sheath that covers nerves, causing irreversible damage and disrupting communication between the brain and body. The breakdown of myelin – called demyelination – can cause symptoms that range in severity from numbness and tingling to blindness and paralysis.

The goal of any MS treatment is to reverse demyelination, which would return proper nerve function and reduce or prevent long-term disability. Rather than reversing the demyelination process, current treatments focus on the autoimmune aspect of the disease, blocking immune cell access to myelin or otherwise lessening the body's inflammatory response.

Now, researchers from the University of California San Francisco have identified an over-the-counter antihistamine called clemastine that can reverse damage to the myelin sheath and, what's more, they've identified a biomarker that can measure the drug's effectiveness.

It all hinges on something called the "myelin water fraction" or MWF. Water that is trapped between the layers of myelin that wrap around nerves in the brain can't move as freely as water that floats between brain cells. The MWF measures the ratio of myelin water to the brain tissue's total water content and indicates myelin integrity.

1 Comments in Response to

Comment by PureTrust
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"Brain Boosters" by Beverly Potter and Sebastian Orfali, is a 1993 book that talks about loads of drugs and nutrients that enhance the brain and nerves. One of the drugs is 'Centrophenoxine' which cleans out waste materials from brain and nerve cells.The drugs in this book are mostly rejected by the FDA, and prohibited for sale in the US. But they are used in Europe and Asia. You can often get generic forms from China and Mexico. Do searches for brain and nerve drugs and nutrients for a bunch of books that talk about all kinds of good chemicals that are being denied us in the USA. A simple on is niacin (vitamin B3), which can reverse senility in older people, if taken in amounts like 1000 to 3000 milligrams a day.