Update (1050ET): 

Starship, the world's largest rocket, blasted off from southern Texas at 0925 ET. The spacecraft separated from its booster and coasted around the planet in space. However, during reentry, with an anticipated splashdown in the Indian Ocean, the signal with the spacecraft was lost. 

Moments ago, SpaceX's Dan Huot said, "We are making the call now that we have lost (the) ship."

Huot continued: "No splashdown today, but again just it's incredible to see how much further we got this time around." 

Musk posted on X, "Starship will make life multi-planetary."