The research team led by Vasily M. Studitsky, professor at the Lomonosov Moscow State University, published their findings in an article "Structure of transcribed chromatin is a sensor of DNA damage" in the Science Advances journal.

"Early detection and repair of damaged DNA is essential for cell functioning and survival," says the study.

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The paper raises the question of single-strand breaks (SSBs) which are called in the research "common DNA damages generated during various processes of cell metabolism."

"Unrepaired SSBs can interfere with transcription, replication, and DNA repair; induce accumulation of double-stranded DNA breaks; increase genomic instability and apoptosis [process of programmed cell death]; and lead to severe neurodegenerative diseases." Alzheimer's, Parkinson's disease and spinal muscular atrophy are examples of such diseases.