While Fischer's term as Vice Chairman of the Fed was set to end next year, he had the ability to serve as a governor through 2020. Along with Trump's decision next year on whether to replace Janet Yellen as the Fed's chair, this means Trumps will have the opportunity to appoint five of seven governors to America's central bank.

Given that the position holds a 14-year term, it is unusual for a president to have the opportunity to make so many appointments. As Diane Swonk of DS Economics noted, "It's the largest potential regime change in the leadership of the Fed since 1936."

Of course the question is now whether a change in personnel will lead to a change in policy.

Trump has already taken steps to fill one of the vacancies, nominating Randal Quarles earlier this year. Quarles, a former Bush-era Treasury official turned investment banker, will be taking the specific role of Fed vice chair of supervision. As a vocal critic of Dodd-Frank, and the Volker Rule in particular, Quarles may help relieve some of the regulatory burden on financial institutions, but his views on monetary policy are less clear.