This ruling, one of Monsanto's largest trial losses in the five-year litigation over the herbicide, raises new questions about the safety of the controversial product and the company's future legal challenges.

In a late Friday decision, jurors awarded James Draeger, Valorie Gunther, and Dan Anderson $61.1 million in actual damages and a staggering $500 million each in punitive damages. They claimed that years of using Roundup on their properties led to their non-Hodgkin's lymphomas. This verdict is one of the largest against a US corporate defendant this year, eclipsing even a significant $1.78 billion verdict in a federal real estate case (which could balloon to more than $5 billion), Bloomberg reports.

Bayer officials said on Saturday that US judges have allowed what they see as mischaracterization of regulatory decisions on Roundup's safety. Despite recent plaintiff victories, the company says it remains confident in overturning these verdicts, citing ongoing regulatory support for glyphosate, Roundup's main ingredient. Bayer plans to phase out glyphosate in the US consumer market by year's end.

Bayer also noted in the statement the US Environmental Protection Agency continues to find Roundup and its main ingredient, glyphosate, as safe and a federal appeals court recently backed a rejection of calls for Bayer to include safety warnings on the product's distinctive white bottles. The company agreed to transition from the version of Roundup containing glyphosate to new active weed-killing ingredients in the US consumer market by the end of the year. -Bloomberg