Foul play is being considered following the third train derailment in Canada this month, after left-wing extremists called on supporters to sabotage the country's rail system.

The incident occurred in Sainte-Marie-Salomé in Canada's French-speaking province of Quebec earlier this week and saw two train cars derailed, with an unnamed source claiming that something had purposely been put on the tracks to derail the train, CTV reports.

CN, Canada's largest rail company, refused to confirm or deny whether they suspected the derailment may have been an intentional act of sabotage but CN senior manager of public affairs Olivier Quenneville did confirm no one had been injured in the incident and no hazardous materials were involved.

"The incident is still under investigation and we will not comment further," Quenneville told the broadcaster.