In an ironic twist of fate, shortly after Midnight on Friday, McCain voted against the Obamacare repeal. It failed 51-49.

CNN reports GOP Obamacare Repeal Bill Fails in Dramatic Late-Night Vote.

The Senate has dealt a devastating setback to Republican efforts to repeal Obamacare, defeating a GOP "skinny repeal" bill early Friday morning.

Sens. John McCain, Lisa Murkowski and Susan Collins joined with Democrats to oppose the measure. McCain, who had voted for a motion to proceed to the bill Monday after returning to Washington following surgery for a brain tumor, held out all day, including in a press conference where he criticized the partisan process that led to the after-midnight vote.