Her statement was a complete U-turn from what she said just over a week ago, when she told a group of reporters that the US was "no longer focused on getting Assad out."
In her CNN interview, Haley also said that defeating the Islamic State, pushing Iranian influence out of Syria, and the ouster of Syrian President Bashar al-Assad are top priorities for Washington.
"There's not any sort of option where a political solution is going to happen with Assad at the head of the regime," Haley told CNN anchor Jake Tapper. "If you look at his actions, if you look at the situation, it's going to be hard to see a government that's peaceful and stable with Assad."
"We don't see a peaceful Syria with Assad in there," Haley added.