The Senate, which last year refused to consider Democratic former President Barack Obama's nominee to the court, voted 54-45 to approve Republican Trump's pick, Colorado-based federal appeals court judge Neil Gorsuch, to the lifetime job. Three Democrats joined the Republicans in voting for Gorsuch.
Gorsuch's confirmation ends the longest Supreme Court vacancy since 1862 during the American Civil War, with the court down a justice for almost 14 months since long-serving conservative Justice Antonin Scalia died on Feb. 13, 2016.
"Judge Gorsuch's confirmation process was one of the most transparent and accessible in history, and his judicial temperament, exceptional intellect, unparalleled integrity and record of independence makes him the perfect choice to serve on the nation's highest court," Trump said in a statement.
"He's going to make an incredible addition to the court," Senate Majority Leader Mitch McConnell said on the Senate floor.