Paxlovid - Pfizer's Covid medication notably taken by Joe Biden, Jill Biden and Dr. Anthony Fauci - before all three had "rare" (and then not-so rare) cases of "rebound Covid" - can have dangerous interactions with some of the most common medications for cardiovascular disease, including various statins and heart failure therapies, according to a Wednesday paper published in the Journal of the American College of Cardiology.

In it, researchers found that the combination of nirmatrelvir and ritonavir, two antivirals which comprise Pfizer's Paxlovid, can interact with a number of commonly prescribed cardiovascular medications. According to the paper, Ritonavir, which was approved to treat HIV in 1996, impacts the CYP450 pathway that's involved in metabolizing a number of medications—as well as the P-glycoprotein drug efflux pump, the Epoch Times reports.

"Co-administration of [Paxlovid] with medications commonly used to manage cardiovascular conditions can potentially cause significant drug-drug interactions and may lead to severe adverse effects," reads an abstract. "It is crucial to be aware of such interactions and take appropriate measures to avoid them."

The paper also notes that interactions between Paxlovid and some blood thinners can cause a higher risk of bleeding, while interactions between Paxlovid and cholesterol medications such as Statins can be toxic, CNN reports, citing the paper.

"Awareness of the presence of drug-drug interactions of Paxlovid with common cardiovascular drugs is key. System-level interventions by integrating drug-drug interactions into electronic medical records could help avoid related adverse events," said lead author Saru Ganatra, MD, who works at Lahey Hospital and Medical Center in Burlington, Massachusetts.