To answer that question, the survivalist website Survivalfreedom.com outlines that some of the safest regions in a nuclear war "include the upper Midwest, Maine, West Texas, and multiple small pockets, usually in areas that don't have large populations." The most dangerous region is the East Coast because of the significant presence of military installations, defense companies, critical infrastructure, and major cities. 

The survivalist website pointed to a Federal Emergency Management Agency (FEMA) map that outlines the most likely targets of Russian Intercontinental ballistic missiles (ICBMs). 

Here's a more refined map of US nuclear targets. 

They said, "based on research of numerous sources, this is the consensus on the least safe and most safe areas in the United States in the event of a nuclear attack." The map below shows red zones are "least safe" while blue zones are "most safe."