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LL 2020 How math is revolutionizing medicine

• arclein

ne reason that an Alzheimer's drug candidate fails is because it targets the wrong pathological substrate. In the last decade, almost all Alzheimer's drug development has focused on amyloid-beta plaques and the subsequent elimination. Different drug candidates target different isoforms, or variants of amyloid beta, and different terminants or ends of the protein. There are quite a number of combinations.