But that was all the trial found: remdesivir isn't the miracle cure that will get us all out of lockdowns tomorrow, unfortunately.

Worse, as Bloomberg's Faye Flam writes, the trial was rushed to get quick FDA approval, without getting helpful information on what kinds of patients it helps or hurts the most; and now that the study is over, we've forever lost a chance to help doctors treat virus patients better.

All of which raises a significant number of questions and Acute Care Surgeon (and Asst Professor of Surgery at Wash U.) Mark Hoofnagle warns "I am truly sorry to say, Remdesivir is probably worthless..."

In an excellent Twitter thread, Hoofnagle details what he calls "some fascinating drug company shenanigans."

First, the pre-test probability that an infused, small-molecule inhibitor of a virus would improve mortality in symptomatic patients was already pretty low. Unfortunately, antivirals work poorly in acute disease. This has to do with their mechanism of action, and host response.