After CNN host Wolf Blitzer asked Paul whether the Soleimani strike made U.S. more or less safe, he warned of possible blowback emanating from the attack.

"I think the stated purpose of the administration was that they were going to prevent attacks on Americans, but I think if you ask the question now: is it more or less likely that there will be attacks on Americans? I think it's much more likely," Paul said in response to Blitzer.

"The replacement for Soleimani is basically a clone. Somebody who is a hardliner, someone who has worked with Soleimani for 20-some odd years, and so while Soleimani may have been plotting attacks and probably was, it is now a certainty that there will be attacks in revenge for his killing," he explained.

Paul also said the attack on Soleimani will embolden the Islamic Republic of Iran and unite Iranians around the regime. The attack will undermine protests that had the theocratic government on its heels in recent months.