The risks of these pharmaceuticals are sometimes several orders of magnitude higher than their natural alternatives. Over-the-counter painkillers have become classical examples of this, with so-called "low-dose" aspirin no longer considered safe enough to use for the primary prevention of cardiovascular disease and stroke, ibuprofen causing tens of thousands of deaths each year due to its recently discovered cardiotoxicity, and Tylenol's adverse effects on the psychospiritual constitution of humanity only just beginning to surface on top of it's already well-established extreme toxicity to the liver.