Deonte Eric Smith and Dieontra Shukur Clark forced their way into a home on the 800 block of Bridge Street after midnight Sunday, according to Eden police.
Officers responded around 12:45 a.m. to find Clark dead and both homeowners with gunshot wounds.
Police believe Smith and Clark broke in intending to rob Deandre Hill and Brianna Aleman.
Shots were fired and Clark, 21, was killed. Hill and Aleman were also shot and needed medical attention.
A 5-year-old in the house was uninjured.
Police are looking for Smith, who they say ran away.