It is hard to estimate how much influence over U.S. domestic and foreign policy John McCain had. With his illness upgraded to a glioblastoma in his head, the likelihood of his return to a policy position is unlikely.

As I predicted earlier this week, the severity of McCain's health problems will inevitably usher in a major power shuffle in Washington.

The Arizona senator's absence creates a unique opportunity for President Trump to alter the course of our foreign and domestic policy. From Iraq to Libya, Syria to Afghanistan and right up to Russia's borders in Ukraine, McCain's bloody paw prints are all over more than a decade of American foreign policy blunders.

Most of these foreign policy nightmares have served, directly or indirectly, to weaken Russia's western and southern flanks and prevent Eurasian integration. And of all the excrement that has exited McCain's mouth, his hatred for Russia has always seemed most sincere. Everything else is politically fungible.