While the permit opens a crack in Mexico's prohibitionist policies, the government health watchdog Cofepris stressed that the authorization is limited to those four people only.
The group, part of the Mexican Society for Responsible and Tolerant Personal Use (SMART), is pushing for full legalization of marijuana, arguing that it will help reduce the country's relentless drug violence.
Their legal victory has set a potential precedent for others to seek similar permits while forcing President Enrique Pena Nieto and Congress to debate whether to change the country's marijuana laws.
For now, Cofepris underlined in a statement that under the current laws marijuana "is still an illegal substance" and its cultivation and sale remain forbidden.
But the four SMART members -- two lawyers, an accountant and a social activist -- are allowed to "sow, grow, harvest, prepare, possess, transport and consume marijuana for recreational uses," Cofepris said.