A road trip gone awry will send the Griffins to Springfield in the one-hour 12th season premiere of "Family Guy."

The episode, which has been in the works for two years according to Entertainment Weekly, will show the Quahog family interacting not only with the Simpsons' family but also engaging with plenty of Springfield's locals.

The big crossover episode will air Sept. 28 on Fox at 9 p.m.

Fox released a bunch of new photos previewing the upcoming episode entitled "The Simpsons Guy," and it looks like one you won't want to miss.

"The Simpsons Guy" will feature each character as they interact with their counterpart when the Griffin family from "Family Guy" accidentally end up in Springfield.